Defoe, who was stretchered off while playing for England late in Tuesday night's 3-1 win over Switzerland in Basle, suffered an ankle knock and the player had insisted he would to be fit to face West Bromwich Albion this weekend.
However, Defoe is now due to miss the first half of Spurs' maiden Champions League campaign and is also a major doubt for England's next Euro 2012 qualifier against Montenegro at Wembley on October 12.
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